Lynn M. Westphal, MD, Mary Lake Polan, MD, PhD, MPH*, Aileen Sontag Trant, PhD
Purpose: To determine the impact of nutritional supplementation on female fertility.
Methods: A double-blind, placebo-controlled study was initiated to determine the effects of FertilityBlend for Women, a proprietary nutritional supplement containing chasteberry, green tea, L-arginine, vitamins (including folate) and minerals, on progesterone level, basal body temperature, menstrual cycle length, pregnancy rate and side-effects.
Results: Ninety-three (93) women, age 24-42 years, who had tried unsuccessfully to conceive for six to 36 months, completed the study. After three months, the FertilityBlend (FB) supplement group (N=53 vs. 40 in placebo group) demonstrated a strong trend toward an increase in mean mid-luteal phase progesterone (from 8.2 to 10.4 ng/ml, p=0.06). Among women initially low in progesterone (<12 ng/ml, N=34 in FB and 23 in placebo group), the increase in the FB group with low progesterone was highly significant (4.9 to 9.3 ng/ml; p=0.005). The average number of days in cycle with basal temperatures over 98F during luteal phase also increased significantly in the overall FB group (5.5 to 8.1 days, p=0.006). Among women starting with short cycles (<27 days, N=15 in FB and N=9 in placebo group), mean cycle length increased significantly in the FB group (from 24.2 to 27.6 days; p<0.001). Among women with longer cycles (>32 days, N=11 in FB and 6 in placebo group), cycles tended to shorten in the FB group (from 41.6 to 31.7; p=0.02). The placebo group overall (N=40) did not show any notable changes after treatment, in any of the parameters studied. After six months, 17 of the 53 women in the FB group were pregnant (32%), and four of the 40 women in the placebo group were pregnant (10%; p<0.01). No significant side effects were noted.
Conclusion: Nutritional supplementation could provide an alternative or complement conventional fertility therapies.
Clinical and Experimental Obstetrician and Gynecology. XXXIII, n. 4, July 2006.
*Dr. Polan is a member of the Scientific Advisory Board and received stock options in the company for her service.
Below are list of published scientific and medical studies that support the effectiveness and safety of the individual ingredients in FertilityBlend.